RETRATUTIDE INJECTION 40mg
RETRATUTIDE INJECTION 40mg
Retatrutide is a novel triple agonist targeting GLP-1, GIP, and glucagon receptors[1], studied for substantial weight loss and metabolic improvement in obesity and type 2 diabetes[2][3]. With an extended half-life of approximately 6 days, this peptide enables convenient once-weekly subcutaneous dosing with a gradual titration protocol to optimize tolerability[1][4].
- Reconstitute: Add 2.0 mL bacteriostatic water → 20.0 mg/mL concentration for optimal weekly doses.
- Typical weekly range: 2–12 mg once weekly (gradual escalation over 12+ weeks).
- Easy measuring: At 10.0 mg/mL, 1 unit = 0.01 mL ≈ 200 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 2–4 weeks.
Standard / Gradual Titration Approach (2 mL = 10.0 mg/mL)
| Week(s) | Weekly Dose (mcg) (mg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–4 | 2,000 mcg (2 mg) | 10 units (0.20 mL) |
| Weeks 5–8 | 4,000 mcg (4 mg) | 20 units (0.40 mL) |
| Weeks 9–12 | 8,000 mcg (8 mg) | 40 units (0.80 mL) |
| Weeks 13+ | 12,000 mcg (12 mg) | 60 units (1.20 mL) — split into 2 injections or use 2 vials |
Frequency: Inject once weekly subcutaneously. This schedule follows clinical trial protocols that demonstrated significant weight loss (up to 24% at 48 weeks with 12 mg weekly)[2] while minimizing gastrointestinal adverse events through gradual escalation[1][4]. Starting at 2 mg weekly (versus 4 mg) significantly reduces initial GI side effects. The 20 mg vial size with 2.0 mL reconstitution provides excellent concentration (10.0 mg/mL) for convenient measuring. For the maintenance dose (12 mg = 1.20 mL), either split into two 0.60 mL injections at different sites or reconstitute an additional vial.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake vigorously).
- Label with reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Note: The 20 mg vial size is highly efficient for weekly protocols. Lower doses (2–8 mg) fit comfortably in a single syringe, while the maintenance dose (12 mg) requires either splitting across two injection sites or using a second vial for the remaining 0.20 mL (2 mg).
